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Research blog

Scientific reviews of research-use peptides - telomeres, regeneration, metabolism, neuroscience and longevity. All information is for research purposes only.

MetabolismPopular

Retatrutide

Retatrutide is a GIP, GLP-1 and glucagon receptor agonist in clinical development. In addition to phase 2 studies, a phase 3 trial in type 2 diabetes was published in 2026, but the compound remains investigational and these findings are not a recommendation for using a laboratory product.

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Longevity

Epitalon

Epitalon is being studied in models of telomere biology, gene regulation and cellular ageing. Most evidence comes from cell cultures or animal studies, so a reliable effect on human longevity cannot currently be claimed.

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Regeneration

BPC-157

BPC-157 is studied mainly in cell, tissue and animal models involving tendon biology, wound healing and the gastrointestinal tract. Controlled human trials and reliable long-term safety data remain very limited.

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Neuroscience

Dihexa

Dihexa is an experimental angiotensin IV analogue studied in HGF/c-Met signalling, synaptogenesis and animal models of memory. Its clinical effectiveness and safety in humans have not been established.

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Metabolism

5-Amino-1MQ

5-Amino-1MQ is an experimental NNMT inhibitor studied in metabolic and adipose-tissue models. Changes in body mass have been reported in mice, but evidence for effectiveness and safety in humans is insufficient.

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Neuroscience

DSIP

DSIP is a historical experimental peptide associated with research on sleep and neuroendocrine regulation. Small, older human studies produced mixed results, while its natural biological role and receptor remain unresolved.

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Regeneration

GHK-Cu

GHK-Cu is a naturally occurring copper–tripeptide complex studied in skin, connective-tissue and wound biology. The evidence base is strongest in cell studies, preclinical models and small trials of topical use.

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Longevity

MOTS-c

MOTS-c is a peptide encoded by the mitochondrial genome and studied in metabolism and exercise biology. Human studies have shown changes in endogenous MOTS-c during exercise, but this is not evidence of a therapeutic effect from synthetic MOTS-c administration.

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Longevity

SS-31

SS-31 (elamipretide) is a peptide that targets mitochondrial cardiolipin. In 2025 it received accelerated US approval for a specific Barth syndrome indication, while clinical results in other diseases remain mixed.

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Regeneration

TB-500

TB-500 is associated with an active sequence of natural thymosin β4, but most scientific literature examines full-length thymosin β4 rather than commercial TB-500. Evidence for the two materials should not be treated as equivalent.

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Immunity

Thymosin Alpha-1

Thymosin Alpha-1 has a considerably broader clinical literature than many experimental peptides, but results depend on the specific indication. A large sepsis trial published in 2025 did not show a clear reduction in 28-day mortality.

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